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Pharmaceutical Chemistry Dissertations and Theses
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Recent Submissions
The synthesis of intermediates for conversion to cortisone analogues
Chemotherapeutic agents in the quinolinol series
Design of Intratumoral Immunostimulant Formulations
Brain delivery of BDNF and a monoclonal antibody for the treatment of neurodegenerative animal models
Physicochemical stability and effector function of IgG4-Fc: impact of photo-induced chemical modification and glycosylation
Analysis of Spa33 and its Role in T3SS Cytoplasmic Sorting Platform of Shigella
Preservation of Human T Cell Membrane Integrity after Drying and Rehydration
Method for Simultaneous Quantitation of Free Carrier Protein and Free Polysaccharide in Glycoconjugate Vaccines by High Performance Liquid Chromatography
Development and biophysical characterization of a hyaluronic acid – vitamin E conjugate as a subcutaneous delivery platform
The Application of Machine Learning Algorithms in Understanding the Effect of Core/Shell Technique on Improving Powder Compactability
Design of Antigen-Specific Immunotherapies Through Modulation of Peripheral Tolerance Pathways
Analytical characterization and formulation development of a trivalent subunit rotavirus vaccine for the developing world
Chemical and Physical Instability of Monoclonal Antibodies Induced by Metal-catalyzed Carbonylation
Utilizing IgG1 Fc As An Immunomodulator
The Degradation of 4-Morpholinoaniline in Aqueous Solution
Characterization, Stabilization and Formulation Design of IgG and Secretory IgA Monoclonal Antibody Candidates during Storage and Administration
Targeted Proteomics for Exosome Analysis and Its Application to Develop Blood Markers of Liver Drug-Metabolizing Enzymes
Degradation of therapeutic proteins: Screening methods and identification of epimerized amino acids and local conformational changes in light exposed proteins
EVALUATING NOVEL ANALYTICAL TECHNIQUES TO ASSESS THE INITIAL STEPS OF PROTEIN AGGREGATION USING VARIOUS ANTIBODY SOLUTIONS
Strategies to improve the immunogenicity of subunit vaccine candidates
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Academic Catalog 2022-2023
Medicinal chemistry and drug discovery, ms.
The Medicinal Chemistry & Drug Discovery MS program integrates aspects of contemporary medicinal chemistry and pharmacology, emphasizing topics most relevant to therapeutics design, discovery, and action. The core curriculum focuses on a combination of synthetic organic chemistry, bioorganic chemistry, analytical chemistry, and pharmacology courses. Specialized, in-depth electives are offered in these areas. The program is designed to develop students’ knowledge of medicinal chemistry through design, synthesis, and pharmacological profiling of novel pharmacotherapeutics as applied to helping solve unmet medical needs. For this purpose, many program graduates have established research careers in the pharmaceutical/biotech industry. Undergraduate prerequisites are general chemistry, organic chemistry, and biochemistry or cell/molecular biology.
Curriculum Requirements
All MS programs in the Department of Pharmaceutical Sciences require a set of core courses taken by every MS student, regardless of program. In addition, students in each program are required to take a defined set of discipline-specific courses and several general electives. The number of specialized and elective courses differs somewhat among programs. The MS degree may be completed on either a full-time or part-time basis and may include an optional research thesis. International students are required to attend the program on a full-time basis.
Internship Requirements and Regulations for Department of Pharmaceutical Sciences
Internships provide an experiential component of the graduate curriculum that fosters professional development through work in industry and hospitals.
- In order to participate in an internship, students must complete two semesters with a grade-point average of 3.200 or better; be in good academic and professional standing (i.e. have no Professionalism Concern forms filed); and have no instances of academic dishonesty or blocks on enrollment.
- In order to be eligible for internship, students must take the Professional Development for Pharmaceutical Sciences ( PHSC 5305 ) course in either the fall or spring semester of their first year.
- Students are in school full-time in addition to working on their internships.
- There are no vacations on co-op/internships. Companies’ sick time policies may vary. Students should check with their employers.
- Students are responsible for finding their own internship and must be honest and accurate representing their experiences on their resumés. Prior to looking for an internship, students must have their faculty advisor approve their resumé and ascertain to the best of their ability that the skills and training of students are as presented.
- Students must not accept more than one position. They must honor the first offer accepted.
- In order to receive a grade for the course, students must write at least two learning goals and a paper describing what they learned, mid- and end of semester. Supervisors for internships will reply to a questionnaire about students’ performance.
- International students must register for Pharmaceutical Science Internship ( PHSC 6401 ) and follow instructions to receive Curricular Practical Training authorization from the Office of Global Services every semester they work. This applies to part-time jobs and volunteer opportunities. International students cannot engage in full-time CPT authorization totaling more than 52 weeks. Doing so will eliminate the possibility of engaging in the post-graduation benefit of Post-Completion Optional Practical Training.
- Students receive 1 academic credit per semester for Pharmaceutical Science Internship ( PHSC 6401 ) . If students want to do an internship for a fourth semester they may do so, but students will only receive a maximum of 3 credits for Pharmaceutical Science Internship ( PHSC 6401 ) . The 4th credit for Pharmaceutical Science Internship ( PHSC 6401 ) will not be added to the student’s degree.
- Taking internship must not extend international students’ visas.
General Policies Common to all MS Programs in the Department of Pharmaceutical Sciences
Grading policy.
Students are expected to maintain a GPA of 3.000 (B) or higher in all coursework. Students whose cumulative GPA falls below 3.000 will receive written notification from the Bouvé Office of Graduate Student Services that they have been placed on academic probation. A student must clear the deficiency and return to nonprobationary status within one semester, unless the course that must be retaken is not offered during the probationary semester. In such a case, the course to be retaken must be completed during the next semester that it is offered, and the GPA must be restored to at least 3.000. Failure to remediate the deficiencies and return to nonprobationary status within the established time limit will result in dismissal from the MS program. Refer to the Bouvé College of Health Sciences policy on Academic Dismissal and Academic Probation Policy for full details.
Progression Requirement
Bouvé College of Health Sciences policy specifies that students register for coursework or continuation credit each semester of the academic year (fall and spring semesters) after they are matriculated as full- or part-time students. Moreover, international students are required to maintain full-time student status during each academic term; consult the Office of Global Services for specific requirements. Domestic students who are not able to register for courses during a particular semester must petition the director of graduate studies in the department for exemption, in writing, and state the reasons for the exemption and their plan for resuming their studies. Approval of the petition will preserve student status in the MS program.
All MS students are expected to complete the degree requirements within two years if enrolled on a full-time basis, or within three to five years if enrolled on a part-time basis. If progress toward the degree is slowed or interrupted for personal reasons, the student so affected must petition the School of Pharmacy and Pharmaceutical Sciences Academic Standing Committee for an extension, detailing the anticipated time to completion. If an extension is approved, the student will be directed to meet with the graduate program director to devise a formal plan to achieve completion of the degree.
Course credits earned in the Bouvé College of Health Sciences Graduate School or accepted for transfer from another institution and not applied to obtain a previous degree are valid for a maximum of seven years. Refer to the Bouvé College of Health Sciences Academic Progression policies and procedures for details.
Academic Honesty and Research Integrity
The Department of Pharmaceutical Sciences has a zero-tolerance policy regarding academic dishonesty and violations of research integrity. It is each student’s responsibility to understand and adhere to the School of Pharmacy and Pharmaceutical Sciences Code of Professional Conduct and to Northeastern University’s Academic Integrity Policy . Definitions of plagiarism, cheating, fabrication, falsification, unauthorized collaboration, and actions that facilitate academic or research dishonesty can be found on the Office of Student Conduct and Conflict Resolution website . The lack of knowledge of these definitions does not excuse the student’s responsibility for upholding them. Offenses of academic honesty and research integrity are egregious violations of ethical standards and may result in disciplinary actions including the student’s immediate dismissal from the graduate program.
SOPPS Professional Code of Conduct
All SOPPS students (BSPS, Pre-professional, MS, and PhD) are expected to adhere to the Code of Conduct .
Master of Science Thesis Option
Students who undertake a thesis are expected to report the results of extended research in a written thesis document and make an original contribution to their field. This work should give evidence of the students’ abilities to conduct independent research and interpret their research results in an acceptable manner. Arrangements are made by students interested in the thesis option with individual laboratory directors as to the availability of MS-student research positions and the specific research focus.
Thesis Registration
Students may receive a maximum of 4 semester hours of credit for MS thesis research. Students should register for Thesis ( PHSC 6990 ) , twice for 2 SH each during the fall and spring semesters of their second full year of study, or after completing 15 credits of study. If completion of the thesis requires additional time, students should register for Thesis Continuation ( PHSC 6996 ) (0 SH).
Thesis Committee
Each student’s thesis committee should be composed of at least three members: two from the sponsoring program and one from outside the student’s program. The outside member may be a Northeastern faculty member. The director of graduate studies for the pharmaceutical sciences department may appoint additional members, as considered necessary for student development. The student's major advisor, in whose laboratory the research is being conducted, will serve as committee chairperson. The student, after consulting with the committee chair, is responsible for calling all thesis committee meetings.
Thesis Proposal
The thesis proposal should be no more than 50 double-spaced pages (12-point font minimum and one-half-inch margins on all sides). This page limit excludes references but includes figures, figure legends, and tables. Aside from these exceptions, the proposal should conform to the format and structure of an NIH grant proposal with four sections: specific aims, background and significance, preliminary studies, and experimental design and methods. See the Department of Pharmaceutical Sciences “Thesis Proposal” document for detailed instructions on the preparation of a thesis proposal and the required forms located on the pharmaceutical sciences homepage .
The thesis proposal must be defended orally before the thesis committee and signed by all thesis committee members before the student undertakes the planned research. The signed cover page of the proposal should be submitted to the director of graduate studies, pharmaceutical sciences department, and to the Bouvé College of Health Sciences Graduate Office.
Thesis Final Defense
The final defense is taken after the student completes the thesis research and all other requirements for the MS degree. The defense deals with the subject matter of the thesis, significant developments in the field, and student’s background knowledge in their field of specialization. The thesis committee conducts the final defense.
At least two weeks prior to the expected date of the oral defense, the written thesis must be circulated to the student's thesis committee. After initial committee evaluation, recommendation may be made that the student clarify or rewrite portions of the thesis before scheduling the final defense. After the thesis committee concurs that the thesis is acceptable, a date is chosen for the final oral examination. At least two weeks prior to the defense, the student should inform the director of graduate studies in the pharmaceutical sciences department so that an announcement can be distributed to faculty and students. The final defense is open to anyone who wishes to attend and typically lasts at least two hours. After presentation of the work by the student, and responses to audience and committee questions, the student’s committee meets in executive session to decide whether the student has successfully defended the thesis. The committee’s decision is then announced to the student. If the committee’s vote is favorable, the student incorporates committee suggestions and the dissertation is signed off and passed on to the director of graduate studies in the department. Requests for a second defense are unusual but may be permitted if the original oral defense was judged significantly inadequate.
Thesis Deadline
The thesis should be written, defended, and signed at least two weeks before the university commencement deadline. Students must submit signed copies of the thesis to the online site designated by the university.
Please visit Bouvé College of Health Sciences Program Learning Outcomes for the specific student learning outcomes for this program.
Complete all courses and requirements listed below unless otherwise indicated.
Core Requirements
A grade of C– or higher is required in each course.
Thesis Option
Thesis credits may count toward the required elective hours.
Program Credit/GPA Requirements
33 total semester hours required Minimum 3.000 GPA required
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2022-2023 Undergraduate PDF
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Dissertations-Theses
Dissertations and theses.
Every graduate student has to write a thesis or dissertation before being awarded a MS or Ph.D degree. Browse abstracts and in some cases the complete text of some of our previous students work on the ETD website .
View a complete list of Ph.D degrees awarded by the chemistry department since 1913.
ETD Submission Process
All theses and dissertations are submitted online. Visit the ETD Website for more information on the process.
Public Presentations
View our events section to find upcoming public presentations by graduate students at the Chemistry department.
Reserve a Room
All students seeking to arrange a room and the publicity for the public portion of their comprehensive defense (if required), thesis (MS) defense, or dissertation (PhD) defense should reserve a room no less than one month in advance of the defense date.
Please contact Mary Beth at [email protected] to make the room reservations. Please contact her with any questions regarding the room reservation process.
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Master in Medicinal Chemistry - Thesis Track Curriculum
Specialization requirements.
- Obligatory Requirements
- Elective Requirements
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University Catalog
Ms in medicinal chemistry.
Satisfactory completion of a bachelor’s degree in chemistry, biology, pharmacy or a related discipline is required. It is assumed the undergraduate training will include differential and integral calculus, college physics, a one-year course in general and inorganic chemistry including a laboratory, a one-year course in organic chemistry including a laboratory, and training in analytical chemistry. An undergraduate course in physical chemistry is recommended.
The admission requirements of the College of Graduate Studies of the University apply. The Graduate Record Exam (GRE) is not required for admission, but is highly recommended for international students.
Medicinal and Biological Chemistry (MBC) Major & Master of Science (M.S.) in Medicinal Chemistry (MC) Option
Students need to meet the requirements for entry into the Bachelor of Science of Pharmaceutical Science (BSPS) program. At the beginning of the second semester of their P1 year (spring semester, third year of study) the student applies for provisional acceptance into the graduate program and identifies an MBC faculty mentor for an in-house internship to be taken during the summer between the P1 and P2 year. Once the BSPS degree is awarded the student will be fully accepted into the graduate program. The internship mentor will become the graduate advisor of the student.
Master’s students need to complete the following courses as partial fulfillment of their requirement for an M.S. degree:
One hour can be taken during each semester (fall or spring, not summer). A minimum of 3 credit hours are required, up to 4 count towards degree completion.
A minimum of 6 hours are required, up to 16 hours count toward degree completion.
Other 5000- to 6000-level courses should be taken as electives, as advised. A minimum of 5 hours of electives are required, but more than 5 hours can be taken and will be counted towards degree completion. Typically, students with more biological interests will take MBC 6550 and/or MBC 6200 as electives and students with more chemical interests will take CHEM 6400 and CHEM 6410 .
The total number of credit hours at the graduate level (course numbers 5000 and 6000) including classroom courses, seminar and M.S. Thesis Research needs to be at least 30. This total can be achieved in different ways by varying the number of seminar, research and electives while maintaining the range limits for each category specified above.
In addition, the following items also must be completed:
- Preparation of a written M.S. thesis based upon the results of an original research investigation performed by the student during the M.S. program at The University of Toledo.
- Successful oral defense of the thesis before the thesis advisory committee (consisting of the thesis adviser and two other members) and presentation of the results of the thesis research in a seminar before the Department of Medicinal and Biological Chemistry.
- Acceptance of this thesis by the M.S. thesis adviser and the thesis advisory committee.
- Maintenance of a cumulative graduate GPA of 3.0 or higher.
- One semester of experience as a teaching assistant. The program believes experience in teaching is critical to solidifying the student's understanding of the basics of the field and improving communication skills.
Program Requirements for the combined BSPS/MS in Medicinal Chemistry
The pre-professional division (year 1 and 2) requirements are the same as for the BSPS program as are the requirements for entry into the professional division. When students enter the professional division of the College of Pharmacy and Pharmaceutical Sciences they are in their P1 year (3rd year of study). The requirements for the P1 and P2 years are listed below:
Medicinal and Biological Chemistry Professional Division Curriculum
The MBC major requires that 3 semester hours of laboratory instruction be taken at the 3000 level or higher in a course taught by the MBC Department. Completion of 3 semester hours of any of the following courses will satisfy this requirement: MBC 3880 , MBC 4850 , MBC 4870 , MBC 4880, MBC 4900 , MBC 4950 , or MBC 4960 . MBC 3850 Microbiology & Immunology Lab, 1 semester hour credit does not satisfy this requirement unless it is taken with an additional 2 credit hours of any of the other approved laboratories listed above.
To be chosen from the MBC electives list. (See College of Pharmacy and Pharmaceutical Sciences Catalogue.)
Internship must be taken in the summer before the P2 year with an in house MBC faculty mentor who will then be the mentor for the M.S. degree.
*Once the B.S.P.S. degree is awarded the student can move from provisional to accepted in the graduate program. Requirements to be fulfilled for the MS MC degree are given directly above.
MBC 4720 , Advances in Drug Design, when offered, will also fulfill the requirement.
*At the beginning of the second semester the student identifies a MBC faculty mentor for an in-house internship and applies for provisional acceptance to the graduate school.
Graduation should be in December giving 3.5 years for the B.S.P.S. MBC degree completion. Once the B.S.P.S. degree is awarded the student can move from provisional to accepted in the graduate program. Requirements to be fulfilled for the MS MC degree are given directly above.
The student would begin the master's portion in the spring semester following the B.S.P.S. MBC graduation at the end of the Fall term, and could complete the M.S. degree by the end of the Spring semester of the following year. Therefore the two degrees, B.S.P.S. MBC and M.S. MC, could be accomplished in 5 calendar years.
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Presented here is a selection of research from the School
This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder.
Recent Submissions
Towards understanding the catalytic properties of lead-based ballistic modifiers in double-base propellants , protein nanopores as a platform for transmembrane nanodevices , electronic spectroscopy of ions of interest to astrochemistry , new nmr methods and their applications in mechanistic studies , repurposing a megasynthase biocatalyst towards the production of industrial surfactants , application of broadband, time-resolved magneto-optics to problems in ultrafast photophysics , linking the molecular composition with peatbog status , group 13 exchange for catalytic turnover , water treatment in rural india using sunlight and low-cost materials , kinetics of a dual nickel and iridium photocatalysed cross-coupling , transborylation as a general turnover strategy for main-group catalysis , immobilised tio₂ mesocrystals and their application in solar cells and photocatalysis , investigations of indole-alkaloid biogenesis through synthesis , thinking inside the box: mechanisms in non-covalent catalysis with pd₂l₄ capsules , source apportionment of organic gas and particulate matter pollutants using concentration and flux measurements in delhi , stereoretentive enantioconvergent multicomponent reactions and total synthesis of (±)-ulodione a , main group salen-based catalysts for lactide ring-opening polymerisation , students’ experience in chemistry laboratory: conceptualising the role of chemistry laboratory learning from students’ end and developing the schema of student needs , occlusion of polymeric capsules in calcite single crystals for storage of active pharmaceutical ingredients , assessment of sers-active nanosensors as a tool for ph measurements within living cells .
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This dissertation comprises three chapters, which focus on the development of new synthetic methodologies and the construction of a screening collection. An Application of the Schmidt Reaction: Construction of an Azasteroid ... Exploration of the Mechanisms of Adjuvanticity for Toll-like Receptor Agonists
Pharmaceutical Chemistry Dissertations and Theses Recent Submissions The synthesis of intermediates for conversion to cortisone analogues Jackson, Peter H. (University of Kansas, 1952-08-31) Chemotherapeutic agents in the quinolinol series Edgerton, William Howard (University of Kansas, 1950-05-31)
The Medicinal Chemistry & Drug Discovery MS program integrates aspects of contemporary medicinal chemistry and pharmacology, emphasizing topics most relevant to therapeutics design, discovery, and action. The core curriculum focuses on a combination of synthetic organic chemistry, bioorganic chemistry, analytical chemistry, and pharmacology ...
Medicinal Chemistry is a multi-disciplinary field of study that utilizes synthetic organic chemistry in conjunction with developments in biochemistry, computational chemistry, molecular biology, and pharmacology to advance drug discovery. Faculty members within the Department of Medicinal Chemistry are actively engaged in research projects that ...
Every graduate student has to write a thesis or dissertation before being awarded a MS or Ph.D degree. Browse abstracts and in some cases the complete text of some of our previous students work on the ETD website. View a complete list of Ph.D degrees awarded by the chemistry department since 1913.
Master in Medicinal Chemistry; Master in Microbiological Sciences of Infectious Diseases; Master in Molecular Genetics and Genetic Toxicology; Master in Molecular Toxicology; Master in Molecular Virology; Master in Neonatal Nursing; Master in Nurse Anesthesia; Master in Occupational Therapy; Master in Oncology and Palliative Care Nursing
Medicinal Chemistry II: Drug Design and Drug Action: 3: MBC 3560: Physiological Chemistry II: Chemical Regulation Of Cells And Organisms: 3: PHCL 3730: BSPS Pharmacology II: Endocrine and CNS Pharmacology: 3: MBC 3880: Medicinal And Biological Chemistry Laboratory (Recommend MBC Laboratory course) 1: 3: MBC 3100
This thesis describes the work of two discrete projects. Chapters 2 to 3 detail the development of new enantioconvergent methodology - stereoretentive enantioconvergent multicomponent reactions. Chapters 4 to 5 detail the ... Main group salen-based catalysts for lactide ring-opening polymerisation
Isolation of chemical constituents of some medicinal herbs and evaluated their antiinflammatory antioxidant adipogenisis and antimicrobiological activities: Reddy, Emani Lakshma: Trimurtulu. G: 24-Mar-2020: Thermodynamic and transport properties of binary liquid mixtures: Rao, Patibandla venkateswara: Ravindhranath k: 24-Mar-2020
Continuous flow chemistry; Synthesis of biologically relevant small molecules; New drugs for tropical infectious diseases; SABRE hyperpolarisation of organic molecules. Bonger group; Boltje group; Löwik group. Publications Publications. Publications; Phd Theses. Education Education. Education; Courses; Internships. Spin-off Spin-off. Spin-offs ...